Neuroendocrinology The Hypothalamic Hormones Jeopardy Template

Function of the hypothalamus	Hypothalamic neurosecretory cells	Hypothalamic hypophysiotropic hormones	Complexities of the hypothalamic-pituitary interactions	Adenohypophyseal hormones
100 Name the three areas of the medial basal hypothalamus that are referred to the endocrine hypothalamus Median eminence, arcuate nucleus, VMH	100 What are the two types of neurosecretory cells Magnocellular and Parvicellular	100 What is the function of hypophysiotropic hormones To modulate the release of the anterior pituitary hormones	100 Give some examples to explain that hypothalamic hormones are multifunctional 1)TRH stimulates TSH and prolactin, 2)SOM inhibits GH release and TSH and PRL	100 What hormone does TRH release from the anterior pituitary? TSH
200 Which is the main gland that contacts the median eminence? Pituitary	200 What are the functions of the magnocellular cells To release neurohormones into the circulatory system	200 What are the six well established hypophysiotropic homrones that regulate release of anterior pituitary TRH,CRH, GnRH, GHRH, somatostatin (SOM), dopamine	200 Give some examples how the pituitary hormones can be transported back into the hypothalamus to act as neruomodulator 1)retrograde axonal transport 2) efferent portal vessels, via blood flow from the pituitary to the hypothalamus3)peripheral blood	200 What hormone release is inhibited by dopamine? prolactin
300 Name some of the functions controlled by the hypothalamus Growth, reproduction, metabolism, stress, temperature control, emotional behavior, motivational arousal, fluid balance, circadian rhythm	300 What are the functions of the parvicellular cells To release hypothalamic hormones into the hypophyseal portal system	300 what is known about the control of alpha-MSH release from the anterior pituitary GABA and dopamine inhibits alpha-MSH release. CRH, HT and NE stimulate alpha-MSH release. No hypophysiotropic hormone other than these classic neurotransmitters has been identified to regulate alpha-MSH secretion.	300 Explain why not all the hypothalamic hormones are secreted into the portal system Hypothalamic hormones act as neuropeptides to modulate neuronal excitability influencing neurotransmitters release because they can be released from other regions other than the hypothalamus.	300 What hormones does GnRH release from the anterior pituitary? LH and FSH
400 Which other brain regions give neuronal information to the hypothalamus Amygdala,hippocampus, spinal cord	400 What is a neuroendocrine transducer Convert neuronal input into hormonal output	400 What classic neurotransmitter also serves as a hypophysiotropic hormone? Dopamine	400 Give an example how pituitary hormones release can be influenced by neuropeptide, neurotransmitters as well as hypothalamic hypophysiotropic hormones It has been shown that GABA is present in the hypophyseal portal blood and that GABA receptor are present in the cells of the pituitary gland. GABA regulates GH secretion and influences TSH secretion.	400 What hormones does CRH release from the anterior pituitary? ACTH and beta-endorphin
500 Name some essential information that the hypothalamus can sense from the bloodstream Temperature and hormone levels	500 Give four examples of neuroendocrine transducer 1)magnocellular neurons that release oxytocin2)the parvicellular neurons that secrete releasing/inhibiting hormones into the hypophyseal portal system30 the adrenal medulla tha responds to sympathetic stimulation with the release of catecholamines4) the p	500 What two hormones are NOT hypophysiotropic hormones because they are released from the magnocellular neurons in the posterior pituitary directly into the circulatory system? vasopressin and oxytocin	500 Explain the concept of negative feedback Production of hypothalamic hormones can be influenced by other hormones produced by the target glands	500 What hormone release is stimulated by GHRH and inhibited by somatostatin (SOM)? Growth hormone (GH)

Neuroendocrinology - The hypothalamic hormones

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