Anatomy & Physiology | Neurotransmission | Neurotransmitters | Prevalence of ADHD | Mydayis Clinical Studies |
---|---|---|---|---|
What is the brain and spinal cord?
The CNS is made up of these 2 areas of the body
|
What is threshold?
Once a neuron reaches a certain voltage, called a ______________, the cell will fire an action potential.
|
What are amino acids, biogenic amines and acetylcholine?
Name the 3 types of small molecule neurotransmitters.
|
What is 4.4 million or 9.2% - 10.7%?
Approximately ________ million children and adolescents in the US have been diagnosed with ADHD, or _________ percent?
|
What is beginning at 2 hours up to 16 hours post-dose?
This is the duration of treatment effect of Mydayis in adolescents, as determined by Study 202.
|
What is the limbic system?
This is closely linked to emotional behaviors and disorders, particularly involuntary motor and visceral reactions.
|
What is negative?
Neurons have a _____________________ resting potential.
|
What are dopamine, norepinephrine, epinephrine, serotonin and histamine.
Name the 5 biogenic amines.
|
What is 10.4 million or 4.4%?
Approximately ________ million adults in the US have been diagnosed with ADHD, or _________ percent?
|
What is beginning at 2 hours up to 16 hours post-dose?
This is the duration of treatment effect of Mydayis 50mg in adults, as determined by Study 201.
|
What is the prefrontal cortex (PFC)?
ADHD is a neurobiologic disorder thought to be associated with alterations in this area of the brain.
|
What are neurotransmitters?
These are released when an action potential reaches the presynaptic terminal. They then cross the synapse to bind to receptors on the post-synaptic neuron.
|
What are glutamate and GABA?
This is the major excitatory neurotransmitter in the CNS; this is the major inhibitory neurotransmitter.
|
What is 50-66%?
Childhood ADHD persists into adulthood what percent of the time?
|
What is ADHD-RS total score?
What was the primary efficacy measure for all double-blind Phase 3 Mydayis trials?
|
What are the thalamus and hypothalamus?
These are the most important parts of the diencephalon.
|
What is the synaptic cleft (synapse)?
This is the space between pre- and post-synaptic neurons and is specialized for release and reception of chemical transmitters.
|
What is the locus coeruleus?
The majority of norepinephrine is located here in the brain.
|
What is 76%?
Heritability of ADHD is estimated at...
|
What is Study 306?
This trial supports the use of Mydayis 12.5mg and 37.5mg once daily in the treatment of adult ADHD.
|
What are working memory, behavioral inhibition, attention and impulsivity?
The prefrontal cortex performs these 4 executive functions.
|
What are reuptake, enzyme degradation and diffusion?
Neurotransmitters are cleared from the synapse these 3 ways.
|
What is moderate?
_________________ levels of DA and NE activity provide optimal prefrontal functioning.
|
What is 32%?
The MTA study showed __________% of children have ADHD alone.
|
What is 12.5mg?
This was the starting dose for all adolescents in dose-optimization Study 305.
|