| How much does it cost? | The history of Epi | The EpiPen market: Who are the players |
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What is $0.10 and $0.95 a vial?
The wholesale cost of a vial of epinephrine in the developing world.
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What is 1901?
The final empirical formula was determined by Aldrich in 1904 and came into empirical use in 1905. Large scale production of synthetic hormone became possible in 1906.
The year that Takamine Jōkichi (a Japanese biochemist) first successfully isolated the pure, crystalline form of epinephrine (which he named adrenalin)
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Who are Mylan & King?
This dynamic duo of manufacturer and marketer have owned 80-90% of the market share for the past decade.
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What is £8.50 (US$11.33) in Britain
The National Health Service pays around £48 (US$64) in order to make them available
The cost to consumer for two Jext autoinjectors in Britain.
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Who is Henry Salter?
This comment in 1859 could be the first description of therapeutic effects of circulating endogenous epinephrine
This English physician said "Asthma is immediately cured in situations of either sudden alarm or violent fleeting excitement"
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Who is Sanofi?
This company voluntarily recalled it's Auvi-Q devices due stating that the products had been found to potentially have inaccurate dosage delivery, which may include failure to deliver drug
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What is $100-200 for two
(As of 2016, approximately $100 in France, approximately $200 in Germany)
The approximate cost of EpiPens in Europe
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Who is Hippocrates?
The Greek verb for “panting”, aazein, forms the basis of asthma’s name. However, advances from palliative treatment towards asthma relief did not start arise until late 19th century century
Asthma was first recognized as a respiratory problem in ancient Egypt and in 450 BCE by this well-known ancient Greek physician
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Who is Teva Pharmaceuticals?
The wholesale price is $300 for a pack of two auto-injectors - equivalent to the cost of Mylan's generic
On August 16, 2018 the FDA approved the first generic EpiPen produced by this company.
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What is CAD $95 each.
Note: The EpiPen is the only available epinephrine autoinjector in Canada
The wholesale price of EpiPen in Canada
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Who is Sheldan Kaplan
Inventor of the first modern epinephrine autoinjector, the EpiPen in mid-1970s
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Who is Heather Bresch
CEO of Mylan Pharmeceuticals since 2012.
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What is $600 for two in 2016?
In the United States, the cost for the most commonly used autoinjector for anaphylaxis.
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