| MOA | Symtpoms/Diagnosis | Counseling Points | Brand/Generic | Treatment |
|---|---|---|---|---|
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How do antidepressants work?
Ease depression by affecting chemical messangers (neurotransmitters) used to communicate between brain cells. They work to regulate mood and help relieve depression.
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In children and adolescents, there seems to be an increase in ?
Antidepressants increased the risk compared with placebo of suicidal thinking and behavior (suicidality) in short-term studies in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders.
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What is the generic for Celexa?
citalopram
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What is therapeutic of choice in depression?
SSRI/SNRI
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MOA of SSRI (and name three of them)
MOA: Inhibits the reuptake of serotonin
citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline |
What are some counseling points for the drug fluoxetine?
- take in the AM
- take with food to avoid GI upset - GERD is common as is dry mouth upon waking - do not abruptly stop, must be tapered off unless MD says otherwise - takes 1-2 weeks to see an affect |
What is the brand name for fluoxetine?
Prozac
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Why do we avoid TCAs?
Increased risk of CV events (35% increase in heart disease)
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What are the signs/symptoms of serotonin syndrome?
& what drug class leads to more severe serotonin toxicity?
high body temp
agitation increased reflexes tremor sweating dilated pupils diarrhea MAOIs |
What is brand name for duloxetine?
Cymbalta
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Quitting an antidepressant suddenly may cause symptoms within a day or two, such as:
anxiety
insomnia or vivid dreams headaches/dizziness tiredness/irritability flu-like symptoms (body aches, chills) nausea depression/mood swings |
What is generic for Pristiq?
desvenlafaxine
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If a patient is taking their antidepressant in the AM and are exeperiencing fatigue/sleepiness throughout the day, what is an appropiate change to therapy?
& name some other common side effects of antidepressant medications
Take in the afternoon instead.
weight changes (usually increased) decreased libido insomnia/sleepiness |
What is brand name for trazodone?
Oleptro
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