Skunk

First used by sucking on coca leaves as early as 1500 BC, epidemic became apparent in 1981.

Agonist at the mu receptor

Relaxation, slowed reaction time, increased appetite, euphoria

HIV, hepatitis, addiction, fatal overdose

Barbies

Known to be used in Pakistan 4800 years ago

Agonist at the cannabinoid receptor

Euphoria, drowsiness, feeling of heaviness in the body, slowed breathing

Dental issues, weight loss, cardiovascular conditions, addiction

Crack

First synthesized in 1938 as a potential treatment for schizophrenia

Antagonist at the dopamine transporter

Increased heart rate, exhilaration, mental alertness, irritability/violent behavior

Insomnia, depression, poor memory, hyperthermia, addiction

Speed

First synthesized in 1912 by Merck, but not developed as a drug until the 1980's when it was used for the treatment of trauma

Agonist at the serotonin 5-HT2a receptor

Hallucinations, lowered inhibition, chills, muscle cramping

Anxiety, numbness, poor memory, nausea

Smack

Marketed as Pervitin during World War II

Antagonist at the NMDA glutamate receptor

Stimulation, headache, slurred speech, loss of motor coordination

Increased blood pressure, aggressive behavior, prostate cancer, cholesterolemia