Drugs that affect the cytoskeleton | Drugs that inhibit DNA replication | Drugs that inhibit transcription/translation | Drugs that inhibit translation | Clinical enzymology |
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What is taxol?
This is an anticancer drug that binds to already assembled tubulin and prevents microtubule disassembly
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What is ciprofloxacin?
this drug inhibits bacterial DNA gyrase
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What is rifampin?
this dug inhibits initiation of transcription by binding to prokaryotic RNA polymerase
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What is puromycin?
This drug prevents elongation via premature termination
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What is isoenzyme?
different forms of an enzyme that performs the same biochemical reaction
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What is phalloidin?
this drugs more tightly to F-actin and promotes excessive polymerization and inhibits cell movement
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What is didanosine (ddI)?
This HIV drug is the nucleoside analog of deoxyadenosine that lacks a 3'-OH and upon incorporation causes DNA chain termination
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What is alpha-amantin?
This toxin is a potent inhibitor of RNA polymerase II in eukaryotes
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What is Phalloidin?
This toxin inhibits RNA polymerase II in eukaryotes
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What is troponin T?
This cardiac marker is a good indicator of an MI
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What is cytochalasins?
this drugs blocks the polymerization of actin
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What is novabiocin?
This drug treats MRSA and staph infections. It inhibits bacterial DNA gyrase
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What is Diphtheria toxin?
this toxin inactivates EF-2 by ADP-ribosylation
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What is cyclohexamide?
This drug prevents elongation by inhibiting eukaryotic peptidyl transferase activity
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What is hepatic viral infection?
A high ALT/AST ratio is characteristic for this type of damage
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What is colchicine?
This is an anticancer drug that prevent polymerization by binding to unpolymerized tubulin molecules
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What is camptothecin
The is drug binds and inhibits topoisomerase I in eukaryotes
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What is streptomycin?
This drug inhibits initiation in translation by binding to the 30s subunit and preventing assembly of the ribosome in prokaryotes
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What is erythromycin (macrolide)?
this drug binds to the 50S unit of the ribosome and prevents translocation
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What are ALP. GGT, Amylase and lipase?
Acute pancreatitis due to gallstones will see an increase in these markers
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What are keratin, vimentin. neurofilaments, lamins and beaded filaments?
Name the classes of intermediates
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What is tenofovir?
This drug is a nucleotide analog of deoxyadenosine monophosphate and competes for incorporation into HIV DNA and results in termination of the chain
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What is tetracycline?
This drug blocks elongation in translation by preventing access to the A site
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What is chloramphenicol?
This drug prevents elongation by inhibiting prokaryotic peptidyl transferase activity. and inhibits mitochondrial translation
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What is alpha-fetoprotein?
an increase in this protein in adults indicates cancer
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