Drugs that affect the cytoskeleton Drugs that inhibit DNA replication Drugs that inhibit transcription/translation Drugs that inhibit translation Clinical enzymology
100
What is taxol?
This is an anticancer drug that binds to already assembled tubulin and prevents microtubule disassembly
100
What is ciprofloxacin?
this drug inhibits bacterial DNA gyrase
100
What is rifampin?
this dug inhibits initiation of transcription by binding to prokaryotic RNA polymerase
100
What is puromycin?
This drug prevents elongation via premature termination
100
What is isoenzyme?
different forms of an enzyme that performs the same biochemical reaction
200
What is phalloidin?
this drugs more tightly to F-actin and promotes excessive polymerization and inhibits cell movement
200
What is didanosine (ddI)?
This HIV drug is the nucleoside analog of deoxyadenosine that lacks a 3'-OH and upon incorporation causes DNA chain termination
200
What is alpha-amantin?
This toxin is a potent inhibitor of RNA polymerase II in eukaryotes
200
What is Phalloidin?
This toxin inhibits RNA polymerase II in eukaryotes
200
What is troponin T?
This cardiac marker is a good indicator of an MI
300
What is cytochalasins?
this drugs blocks the polymerization of actin
300
What is novabiocin?
This drug treats MRSA and staph infections. It inhibits bacterial DNA gyrase
300
What is Diphtheria toxin?
this toxin inactivates EF-2 by ADP-ribosylation
300
What is cyclohexamide?
This drug prevents elongation by inhibiting eukaryotic peptidyl transferase activity
300
What is hepatic viral infection?
A high ALT/AST ratio is characteristic for this type of damage
400
What is colchicine?
This is an anticancer drug that prevent polymerization by binding to unpolymerized tubulin molecules
400
What is camptothecin
The is drug binds and inhibits topoisomerase I in eukaryotes
400
What is streptomycin?
This drug inhibits initiation in translation by binding to the 30s subunit and preventing assembly of the ribosome in prokaryotes
400
What is erythromycin (macrolide)?
this drug binds to the 50S unit of the ribosome and prevents translocation
400
What are ALP. GGT, Amylase and lipase?
Acute pancreatitis due to gallstones will see an increase in these markers
500
What are keratin, vimentin. neurofilaments, lamins and beaded filaments?
Name the classes of intermediates
500
What is tenofovir?
This drug is a nucleotide analog of deoxyadenosine monophosphate and competes for incorporation into HIV DNA and results in termination of the chain
500
What is tetracycline?
This drug blocks elongation in translation by preventing access to the A site
500
What is chloramphenicol?
This drug prevents elongation by inhibiting prokaryotic peptidyl transferase activity. and inhibits mitochondrial translation
500
What is alpha-fetoprotein?
an increase in this protein in adults indicates cancer






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