Basic Concepts and Principles of CRRT Part 1 Basic Concepts and Principles of CRRT Part 2 Continuous Renal Replacement Therapies Hybrid Therapies Fluid Concepts
100
What is movement of fluid through a semi-permeable membrane driven by a pressure gradient called hydrostatic pressure?
Ultrafiltration
100
What is forced movement of solutes with fluid or What is "solvent drag"?
Convection
100
What is Slow Continuous Ultrafiltration (SCUF)?
Continuous removal of fluid from the blood in response to hydrostatic pressure as it passes across a semipermeable membrane.
100
What is Prolonged Intermittent Renal Replacement Therapy?
PIRRT
100
What is the % of water in an adult body?
40-60% of adult body weight
200
What is the molecular adherence to the surface or interior of the membrane?
Adsorption
200
What is Continuous Venovenous Hemodialysis Filtration?
CVVHDF
200
What is CVVH?
Clearance is largely convective.
200
What is Slow Low Efficiency Daily Dialysis?
SLEDD
200
What is 60% intracellular fluid, 40% extracellular fluid?
60%, 40%
300
What is the movement of solutes only from an area of higher concentration to an area of lower concentration?
Diffusion
300
What are continuous renal replacement therapies?
SCUF, CVVH, CVVHD, CVVHDF
300
What is CVVHD?
Clearance is largely diffusive
300
What are patients that may need CRRT?
Fluid overload, AKI, Life-threatening electrolyte imbalance, 3rd degree burns, lithium overdose
300
What is intravascular fluid?
7% fluid
400
What is
Osmosis
400
What is membrane selectivity?
Urea, creatinine, glucose, Vitamin B12, Beta 2 M are able to go through but not cytokines nor albumin
400
What are convective and diffusive clearance?
The processes of clearing toxins and intermediators in CVVHDF?
400
What is effluent (dialysate+ replacement fluid +patient net UF) divided by patient weight in kg?
CRRT dose
400
What are the fluid types?
Isotonic, hypertonic and hypotonic
500
What are the major factors affecting diffusion?
Concentration gradient, dialysate flow rate, molecular size, permeability of the membrane
500
What are the major factors affecting convection?
High Membrane permeability
Molecular size
Degradation of filter membrane
Replacement fluid flow rate
500
What is CVVHD?
Uses dialysate, does not use replacement fluid and removes fluid and some Solutes
500
What is SLEDD?
Qb 100-200 mL/min; Qd of 100-300 mL/min with UF 0-500 mL/hr
500
What are mechanisms that maintain fluid balance?
renin, aldosterone, ADH ANP, thirst






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