| Disease Trivia | Medications | Gotta know it | General Q's | Heme Emergencies! |
|---|---|---|---|---|
|
PML-RARA aka t(15;19)
What mutation is diagnostic of APL?
|
Cytarabine and Idarubicin/Daunorubicin
What chemotherapy is in 7+3?
|
65 years old
What is the typical age cutoff for transplant?
|
They all prolong the QTc
What do medications like Levaquin, Fluconazole, Zyprexa, Celexa, and Zofran share in common?
|
Headache, vision changes, dyspnea. Elevated WBC with absolute blasts >50,000 in AML. Urgent leukapheresis
Describe the presentation (exam findings) and management of leukostasis.
|
|
20% (in the bone marrow or peripheral blood)
What is the blast cutoff for acute leukemia?
|
Tyrosine Kinase Inhibitors
What class of medication is Dasatinib?
|
Day 14
On what day do patients get their first bone marrow biopsy after 7+3?
|
DIC
What does a prolonged INR, aPTT, and low fibrinogen suggest?
|
Differentiation syndrome. Diuresis and steroids!
Your APL patient started ATRA and Arsenic 2 days ago and has since gained 7 kg and is dyspneic and hypoxic. What are you worried about?
|
|
Allogeneic stem cell transplant (ASCT)
What kind of transplant is used for leukemia? Allo or Auto?
|
Philadelphia chromosome (BCR-ABL fusion), used in ALL and CML
What do TKI's like Ponatinib target?
|
Acyclovir, Levaquin, Caspofungin
What is the antimicrobial prophylaxis for ALL patients receiving induction chemotherapy?
|
level <150 if bleeding, <100 in general
What is the cutoff to replace fibrinogen?
|
APL
This malignancy, considered a medical emergency, presents with leukocytosis, blasts, Auer rods on peripheral smear, and coagulopathy.
|
|
Leukemia cutis
What is it called when leukemia deposits in the skin?
|
Vincristine
What chemotherapy, if accidently given intrathecally, will cause sudden death?
|
Acyclovir, Levaquin, Posaconazole
What is the antimicrobial prophylaxis for AML patients receiving induction chemotherapy?
|
Direct bilirubin, LDH, reticulocytes, haptoglobin, peripheral smear, and Coombs
What is the initial workup for hemolysis?
|
Cytarabine-induced cerebellar toxicity
Your patient is receiving their 2nd cycle of HiDAC and suddenly develops ataxia. What are you worried about?
|
|
RUNX1, CBFB (inv(16)), or PML-RARA
What mutation is diagnostic of AML, even if blasts are <20%
|
midostaurin, gilteritinib, sorafenib, lestaurtinib, sunitinib, tandutinib, quizartinib, crenolanib, cabozantinib
Name three FLT3-inhibitors
|
>20,000
How high do you have to keep platelets for someone on Dasatinib?
|
II, VII, IX, and X (and proteins C and S)
What are the Vitamin K dependent clotting factors?
|
Blinatumomab
This therapy, used for relapsed ALL, can cause CRS and neurotoxicity.
|
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