This perpetuates the type 2 inflammatory cascade and its effects through a positive feedback loop

IL-5, IL-4, IL-13, IL-31

Key mediators of Type 2 inflammation

Blocks IL-4 from binding to its receptor (IL-4Ra) on the cell's surface

Inhibiting the signaling of both may help control type 2 inflammation

Categorized as either T-Cell or Non-T-Cell source

They impact skin barrier dysfunction

This cytokine mediates tissue remodeling and fibrosis

This important cytokine drives Th2 differentiation

T-cell sources that are responsible for inflammation

Responsible for the initial and continued Th2 differentiation & expansion

This works beneath the skin's surface, specifically targeting IL-4 and IL-13 signaling

Allergens, irritants, pollutants, nanoparticles, microbes all enter through this part of the skin

Non-T-cell sources that are responsible for inflammation

They have overlapping and distinct roles in perpetuating inflammation & skin barrier dysfunction in AD.

Targeting this receptor blocks the signaling of IL-4 and IL-13

Impact skin barrier dysfunction

This cytokine takes a naive T-cell and turns it into Th2

They play a role in driving the itch-scratch cycle

Approved to treat 3 indications driven by type 2 inflammation