Treatment | session 1&2 | more questions |
---|---|---|
Hodgkin Lymphoma
For stage I and IIA, radiotherapy only can be applied.
Radiotherapy can also be used to treat bulky tumor masses of this disease that remain after chemotherapy |
Flow Cytometry
The number of blasts required per 100k cells to detect disease by using this technique is 10
|
(pick 2)
Based on blood count Morphological appearance on blood cells Number of blast cells Cytogenetics
Mention 2 classifications of MDS
|
AML
Besides intensive chemotherapy using cytosine arabinoside and daunorubicin, FLT3 inhibitors can be used to treat this disease
|
Chronic myeloid leukemia (CML)
A cell positive for bcr/abl rearrangement is associated with this disease
|
Epstein-Barr
Pathogenesis of Hodgkin Lymphoma includes Ig gene rearrangement and this virus genome
|
CML
Imatinib, Nilotinib, Dasatinib, Bosutinib, Ponatinib
or Tyrosine kinase inhibitors |
Molecular studies (PCR, RT-PCR)
This detection method is more sensitive than Fluorescence in situ hybridization (FISH)
|
S: Splenic/involvement of spleen
E: localized Extranodal extension from a mass of nodes
What do the subscripts "S" and "E" mean in clinical staging of Hodgkin Lymphoma
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MDS
After deciding low risk or high risk based on IPSS, low risk of this disease can be treated by improving marrow function, blood transfusion, and allogenic stem cell transplantation
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Red cell precursors
Which cell precursor corresponds to Polycythaemia (rubra) vera?
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Bone marrow failure
Organ infiltration lymph node predominate w <20% blasts on marrow > lymphoblastic lymphoma > ALL
Clinical Features of ALL (2+1)
|
Percentage of marrow blasts
IPSS classification is based on this, type of karyotype abnormality, number and severity of cytopenias.
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Hemopoietic stem-cell transplantation
What is the only known cure for myelofibrosis?
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Genetic damage
Accumulation of blast cells in the bone marrow
Pathogenesis of AML (2)
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