Patent Ductus Arteriosus Jeopardy Template

Medication	Durations/Risk Factors	Side Effects/MOA/Route
100 Indomethacin Which medication can be used as a prophylactic agent for PDA to decrease incidence of IVH. but does not improve overall morbidity and mortality?	100 72 hours (3 days) How long does it a take for a term baby’s PDA to functionally close?	100 GI Bleeds What is the main concerning side effect of ibuprofen?
200 APAP Which medication is currently not FDA approved for PDA?	200 3 days What is the duration of therapy for PO APAP for PDA?	200 Oral According the current literature, which route of ibuprofen and APAP seems to be “better”?
300 APAP Which medication was shown to treat PDA most rapidly?	300 3 doses What is the duration of therapy for PO ibuprofen for PDA?	300 Prostaglandin Which hormone is thought to be responsible for PDA?
400 Chlorothiazide, because furosemide increased the incidence of PDA through a prostaglandin-mediated process. Which medication is used to treat fluid-overloaded babies with PDA and why?	400 a. Premature infants (<30 weeks gestational age) b. Premature infants with respiratory distress syndrome c. Very low birth weight (VLBW) infants (<1500 g) (Incidence in this population is ~30%) d. Surfactant therapy decreases pulse pressure increases atrial pressure PDA e. Mechanical ventilation f. Genetic conditions such as Down syndrome g. Mothers who had German measles (rubella) during pregnancy h. PDA is twice as common in girls as it is in boys List two risk factors of PDA?	400 Decreased risk of NEC and transient renal insufficiency Why is ibuprofen preferred over indomethacin (2 reasons)?

Patent Ductus Arteriosus

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