Temperature trauma associated with destruction of the epidermis however, irreversible dermal damage is not evident.

RUBOR – REDNESS DUE TO INCREASED VASCULARITY
CALOR – INCREASED HEAT DUE TO INCREASED BLOOD FLOW
TUMOR – INCREASE IN SIZE – SWELLING (EDEMA) DUE TO LEAKAGE OF FLUID (TRANSUDATION) DUE TO LEAKAGE OF CELLS (EXUDATION)
DOLOR – PAIN - PRESSURE OF INCREASED FLUID (EDEMA)
ON NERVE ENDINGS AND/OR RELEASE OF CHEMICAL MEDIATORS (KININS)
FUNCTIO LAESA – LOSS OF TISSUE FUNCTION

PURULENT EXUDATE IN A SEROUS SPACE
(MESOTHELIAL LINING)
for example:

PERICARDIUM
PLEURAL SPACE
PERITONEUM

IN INFLAMMATION ________ BRING ABOUT: VASCULAR DILATION,
INCREASED VASCULAR PERMEABILITY, CHEMOTAXIS (CHEMICAL ATTRACTION),
INCREASED EMIGRATION OF LEUKOCYTES.

FIBRIN FORMS A WEB BETWEEN THE TWO
EDGES. FIBROBLASTS BIND THE WOUND
EDGES TOGETHER BY DEPOSITING COLLAGEN.

THE SKIN SURFACE GROWS (REGENERATION)
OVER. USUALLY THE 7TH DAY UNION IS COMPLETE

Chemistries from different people might react differently, in response to chemical agents

This RESPONSE DILUTES,
WALLS OFF AND/OR DESTROYS THE
INJURIOUS AGENT AND/OR THE
DYING CELLS.

SEROUS SPACES – EMPYEMA
LIVER – JAUNDICE
KIDNEY – HEMATURIA
LUNGS – HEMOPTYSIS
STOMACH - HEMATEMESIS

MARGINATION

PAVEMENTING

EMIGRATION

BLOOD AND EXUDATE FORMS A SCAB OR CRUST.
BENEATH THE CRUST THE INFLAMATORY PROCESS
IS ACTIVE.

GRANULATION TISSUE FORMS AND EPIDERMAL
CELLS CONTINUE TO PROLIFERATE. THE END
PRODUCT IS A SCAR.

Some examples are:
ADENOVIRUS-SINUS INFECTION
HEPADNA VIRUS-HEPATITIS
HERPESVIRUS-COLD SORES, ZOSTER
PAPILLOMAVIRUS-WARTS

INFLAMMATION IN THE CONNECTIVE TISSUE
WHERE NECROSIS IS NOT VERY EXTENSIVE.

COLLECTION OF MACROPHAGES (HISTIOCYTES OR EPITHELIOID CELLS)
WHICH MAY BE SUROUNDED BY FIBROUS TISSUE.

THEY MAY HEAL BY SCARRING, BECOME CALCIFIED OR DEMONSTRATE CENTRAL NECROSIS.

WHITE CELLS ADHERE TO THE
ENDOTHELIAL LINING OF VENULES.

CONNECTIVE TISSUE REPAIR
- GRANULATION TISSUE

ERYTHEMA - REDNESS
EDEMA – FLUID INCREASE
NECROSIS – CELL/TISSUE DEATH
REPAIR – EPITHELIAL/CT TISSUE
are systemic effects of what?

PROLIFERATING ENDOTHELIAL CELLS

PROLIFERATING FIBROBLASTS

CHRONIC INFLAMMATORY CELLS
MACROPHAGES
LYMPHOCYTES

ENZYMATIC PROTEINS THAT INTERACT TO COMBINE WITH AN ANTIGEN/ANTIBODY COMPLEX.

AS MUSCULES RELAX, VASCULAR SWELLING CAUSES DILATATION, THE ENDOTHELIAL CELLS ARE SPREADING APART.

FIBROUS TISSUE RESPONDING
TO TUMOR

(BRUISE) FORCE OF IMPACT IS TRANSMITTED THROUGH THE SKIN
TO UNDERLYING ORGANS WITH ENOUGH INTENSITY TO DAMAGE

STERILE FLUID CONTAINING FEW CELLS WITH A SPECIFIC GRAVITY
LESS THAN 1.015 AND A PROTEIN CONTENT LESS THAN 3 gm%.
THE CONTENT IS CLEAR AND USUALLY RICH IN ANTIBODIES (AB).

LYSOSOMES OF DEAD OR DYING CELLS RELEASE

AN ACTIVATOR called _______________WHICH

REACTS WITH AN INACTIVE PRECURSOR FROM

THE BLOOD (KALLIKREINOGEN) WHICH RELEASES

THE LEUKOCYTES ENTER THE BASEMENT MEMBRANE AND PASS THROUGH THE VESSEL WALL BY
AMEBOID ACTIVITY.

WEAKNESS/EXHAUSTION