| Definitions | Equation/Formulas | Elimination | Miscellaneous | Pharm nerds | 
|---|---|---|---|---|
| 
						
					 
					  What is ADME and what drug does to body					 
					
					 pharmacokinetics; absorption, distribution, metabolism, excretion 
					 | 
				
				
						
					 
					  What is clearance times concentration					 
					
					 rate of elimination 
					 | 
				
				
						
					 
					  What is applicable to most drugs in regards to elimination					 
					
					 First order elimination 
					 | 
				
				
						
					 
					  What is another term for how long it takes for half of that drug to go away					 
					
					 Half life 
					 | 
				
				
						
					 
					  What is concentration that will produce a desired effect					 
					
					 target concentration 
					 | 
						
| 
						
					 
					  What is achieve desired beneficial effect with minimal adverse effects					 
					
					 rational dosing 
					 | 
				
				
						
					 
					  what is drug amount in body divided by concentration in blood					 
					
					 volume of distribution 
					 | 
				
				
						
					 
					  What is applicable to some drugs in regards to elimination					 
					
					 Zero order elimination 
					 | 
				
				
						
					 
					  What is equation for time required to reach target concentration in blood in steady state administration					 
					
					 4(T1/2) 
					 | 
				
				
						
					 
					  ideal body weight for male that is obese and 5 foot 5 inches					 
					
					 61.5kg 
					 | 
						
| 
						
					 
					  What is the theoretical space available in the body to contain drug					 
					
					 volume of distribution 
					 | 
				
				
						
					 
					  What is Toxic dose divided by effective dose					 
					
					 therapeutic index 
					 | 
				
				
						
					 
					  What is it called when clearance remains constant and ROE varies with concentration					 
					
					 First order 
					 | 
				
				
						
					 
					  What is when dose interval is shorter than 4 half lives, toxic effects seen					 
					
					 accumulation 
					 | 
				
				
						
					 
					  What is 20ng/mL in L terms					 
					
					 20,000 ng/L 
					 | 
						
| 
						
					 
					  What is ability of body to eliminate drug					 
					
					 Clearance 
					 | 
				
				
						
					 
					  What is 0.7Vd divided by Clearance					 
					
					 half life (T1/2) 
					 | 
				
				
						
					 
					  What is it called when ROE remains constant, clearance and concentration vary					 
					
					 Zero order 
					 | 
				
				
						
					 
					  What is the only two reasons clearance will be high					 
					
					 high extraction ratio and high blood flow 
					 | 
				
				
						
					 
					  What is 20,000ng/L in ug terms					 
					
					 20ug/L 
					 | 
						
| 
						
					 
					  What is high when most of the drug leaves the blood and goes elsewhere					 
					
					 Volume of distribution 
					 | 
				
				
						
					 
					  What is clearance times target concentration divided by bioavailability ALL times interval					 
					
					 dosing rate intermittent, not steady state 
					 | 
				
				
						
					 
					  What is another name for zero order elimination					 
					
					 capacity limited elimination 
					 | 
				
				
						
					 
					  What is another name for barriers drug has to cross and how effectively it crosses					 
					
					 Bioavailability 
					 | 
				
				
						
					 
					  What is 20ug/L in mg terms					 
					
					 .02mg/L 
					 |