Definitions Equation/Formulas Elimination Miscellaneous Pharm nerds
100
What is ADME and what drug does to body
pharmacokinetics; absorption, distribution, metabolism, excretion
100
What is clearance times concentration
rate of elimination
100
What is applicable to most drugs in regards to elimination
First order elimination
100
What is another term for how long it takes for half of that drug to go away
Half life
100
What is concentration that will produce a desired effect
target concentration
200
What is achieve desired beneficial effect with minimal adverse effects
rational dosing
200
what is drug amount in body divided by concentration in blood
volume of distribution
200
What is applicable to some drugs in regards to elimination
Zero order elimination
200
What is equation for time required to reach target concentration in blood in steady state administration
4(T1/2)
200
ideal body weight for male that is obese and 5 foot 5 inches
61.5kg
300
What is the theoretical space available in the body to contain drug
volume of distribution
300
What is Toxic dose divided by effective dose
therapeutic index
300
What is it called when clearance remains constant and ROE varies with concentration
First order
300
What is when dose interval is shorter than 4 half lives, toxic effects seen
accumulation
300
What is 20ng/mL in L terms
20,000 ng/L
400
What is ability of body to eliminate drug
Clearance
400
What is 0.7Vd divided by Clearance
half life (T1/2)
400
What is it called when ROE remains constant, clearance and concentration vary
Zero order
400
What is the only two reasons clearance will be high
high extraction ratio and high blood flow
400
What is 20,000ng/L in ug terms
20ug/L
500
What is high when most of the drug leaves the blood and goes elsewhere
Volume of distribution
500
What is clearance times target concentration divided by bioavailability ALL times interval
dosing rate intermittent, not steady state
500
What is another name for zero order elimination
capacity limited elimination
500
What is another name for barriers drug has to cross and how effectively it crosses
Bioavailability
500
What is 20ug/L in mg terms
.02mg/L






Pharmacokinetics

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