Definitions | Equation/Formulas | Elimination | Miscellaneous | Pharm nerds |
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What is ADME and what drug does to body
pharmacokinetics; absorption, distribution, metabolism, excretion
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What is clearance times concentration
rate of elimination
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What is applicable to most drugs in regards to elimination
First order elimination
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What is another term for how long it takes for half of that drug to go away
Half life
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What is concentration that will produce a desired effect
target concentration
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What is achieve desired beneficial effect with minimal adverse effects
rational dosing
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what is drug amount in body divided by concentration in blood
volume of distribution
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What is applicable to some drugs in regards to elimination
Zero order elimination
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What is equation for time required to reach target concentration in blood in steady state administration
4(T1/2)
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ideal body weight for male that is obese and 5 foot 5 inches
61.5kg
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What is the theoretical space available in the body to contain drug
volume of distribution
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What is Toxic dose divided by effective dose
therapeutic index
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What is it called when clearance remains constant and ROE varies with concentration
First order
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What is when dose interval is shorter than 4 half lives, toxic effects seen
accumulation
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What is 20ng/mL in L terms
20,000 ng/L
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What is ability of body to eliminate drug
Clearance
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What is 0.7Vd divided by Clearance
half life (T1/2)
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What is it called when ROE remains constant, clearance and concentration vary
Zero order
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What is the only two reasons clearance will be high
high extraction ratio and high blood flow
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What is 20,000ng/L in ug terms
20ug/L
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What is high when most of the drug leaves the blood and goes elsewhere
Volume of distribution
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What is clearance times target concentration divided by bioavailability ALL times interval
dosing rate intermittent, not steady state
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What is another name for zero order elimination
capacity limited elimination
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What is another name for barriers drug has to cross and how effectively it crosses
Bioavailability
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What is 20ug/L in mg terms
.02mg/L
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