Basic Neurotransmitters + Receptors | Biostatistics + Genetics | Chronic “Organic” disorders | Neuroanatomy + Neuroimaging | ASD/ID+LD/ADHD/kiddo disorders |
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What are
MICROGLIA
This cell type secretes innate pro-infammatory cytokines (TNF-alpha and IL-1B) in patients
with inflammatory conditions that affect the brain. |
What is
ANOVA (tests for more than two groups on a continuous variable)
Groups of patients with MDD, dysthymia, and adjustment disorder were given mood scales. This would be the most appropriate statistical analysis to compare the means of their scores.
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What is
TRANSVERSE MYELITIS
This condition is a forerunner of MS.
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Where is the
RIGHT PARIETAL LOBE
60 y/o right-handed M, getting lost, only writes on right half of paper. Left-sided hemi-neglect. The lesion is located here.
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What are
MIXED AMPHETAMINE SALTS or DEXTROAMPHETAMINE
A child with ADHD fails a trial of methylphenidate. These two medications are considered the next step in pharmacotherapy.
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What is
OBLIGATE CO-AGONIST (one half of the agonizing key)
This is the role of glycine at the NMDA receptor.
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What is
ARYL SULFATASE
Metachromatic leukodystrophy is associated with mutation in the gene for this enzyme.
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What is
APOLIPOPROTEIN E-4
When combined with functional neuroimaging, this biomarker is most
likely to identify geriatric pts with mild cognitive impairment most at risk for developing Alzheimer’s disease. |
What is a
LATERAL MEDULLARY STROKE
This event could cause a 66 y/o with HTN to develop vertigo, diplopia, nausea, vomiting, hiccups, L face numbness, nystagmus, hoarseness, ataxia of limbs, staggering gait, and tendency to fall to the left.
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What is
SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITION
This is atomoxetine’s principal mechanism of action.
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What is the
NUCLEUS ACCUMBENS
Dopamine release is a common final event associated with reinforcing the effects of opiates, cocaine, amphetamines, nicotine, PCP, and alcohol in this structure of the brain.
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What is
LAST OBSERVATION CARRED FORWARD
This statistical method attempts to address the effects of participants dropping out of a
study prior to completion. |
What is
INFORMATION PROCESSING SPEED
This domain of neurocognitive function is the most likely to show decline in people over 65 years of age.
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What is the
CEREBELLUM
26 y.o. w/HA and R-hand clumsiness for weeks. Exam shows difficulty w/rapid alternating
movements of hand, overt intention tremor on finger-to-nose, and mildly dysmetric finger tamping. CNS intact and no papilledema. This structure of the brain is most likely damaged. |
What is
INTELLECTUAL DISABILITY
This is the most common comorbid condition in children with autism.
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What is
CHOLINERGIC
This neurotransmitter system is the last to mature in the CNS of children and adolescents.
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What is
SCHIZOPHRENIA
Adolescents with velcardiofacial syndrome (chromosome 22q11 deletion syndrome) are at substantially increased risk for developing this psychiatric disorder.
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What is
PROGRESSIVE SUPRANUCLEAR PALSY
66 y/o c/o frequent falls, several-month hx of anxiety, unwillingness to leave home. On
exam, mild impairment of vertical gaze on smooth pursuit/ saccades, mild axial rigidity & minimal rigidity of upper extremities, along w mild slowness of movement on finger tapping, hand opening & wrist opposition. Posture nml. Gait tentative/awkward, but w/o shuffling, ataxia, tremor. Pt is slow in arising from a chair. This is the most likely diagnosis. |
Where is the
HIPPOCAMPUS
In adults, this is the location of most cerebral neurogenesis.
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What is
HYPERACTIVITY BECOMES LESS SEVERE INATTENTION REMAINS THE SAME
ADHD has two domains of symptoms. As children grow, this usually happens to the severity of the symptoms in each domain.
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What is
GHB
This compound increases muscle mass by increasing episodic secretion of GH.
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What is
Z-SCORE (Z = 2.0 means the value is 2 SD from the mean, AKA p =0.05)
This measure is used to report the deviation of a value from its group mean, expressed in standard
deviation units. |
What is
HYPOTHALAMIC HAMARTOMA
9 y/o F has 3 month h/o seemingly unprovoked bouts of laughter. Worse when not
sleeping well. Pt does not feel happy during these episodes. Started menstruating 6 months ago, and at Tanner stage 4. The diagnosis is... |
What is
DIFFUSION WEIGHTED MRI
This MRI technique is most likely to reveal early signs of ischemic stroke.
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What is
LANGUAGE DEVELOPMENT (delayed in Autism, normal in Asperger's)
While there is a strong correlation between autism and Asperger's, function in this domain is a key distinguishing feature.
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