| Antiemetics | Pain Management |
|---|---|
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What is the duration of activity of fosaprepitant?
~3 days
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What is a recommended supportive care measure for patients on scheduled opioids?
Bowel regimen (stimulant laxative preferred)
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What are the adverse effects/monitoring for 5HT3 RA?
Headache, constipation, QTc prolongation
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You notice a patient is taking oxycodone-APAP 5-325 mg PO PRN. Do you have any recommendations?
Remove the APAP and continue oxycodone 5 mg PRN if well controlled.
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What is the mechanism of metabolism for NK-1 RA?
CYP3A4 (don't forget about drug interactions!)
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What is the one opioid without active metabolites and not renally cleared?
Fentanyl
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What are the appropriate PRN antiemetics for a patient receiving pre-medications including ondansetron, fosapreptiant, and dexamethasone?
1st choice: dopamine antagonist (prochlorperazine or olanzapine)
2nd choice: benzodiazepine (lorazepam) |
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The team asks you to start dexamethasone for nausea for a patient D+3 MUD now receiving PTCy. What is your response/any concerns?
No steroids with PTCy!
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