| Evolving Definition | More or Less Monitoring | More or Less Fluid | More or Less Vasopressors | More or Less of Other Things |
|---|---|---|---|---|
|
What are Infection, Immune dysregulation, and Organ dysfunction?
The 3 key elements of the Sepsis-3 definition.
|
What is central venous saturation?
An aspect of septic patients' monitoring that was disproven useful in studies like ProCESS, ARISE, and ProMIse
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What is 20cc/kg?
The recommended amount of crystalloids to administer to septic patients upon presentation.
|
What is norepinephrine?
The go-to vasopressor in septic patients.
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What is 200-300mg/day for 5-7 days (no tapering off)?
The recommended daily dose and duration of steroids recommended for patients in septic shock?
|
|
What are the Need of vasopressors, and Serum Lactates above 2
The 2 key elements of the septic shock definition
|
What are Sending cultures, Starting antibiotics, Giving fluids, Sending lactates, and Starting vasopressors as needed
Five things to be done within an hour of suspecting sepsis?
|
What is 3-6h?
The time period after a sepsis diagnosis where aggressive fluid resuscitation is most likely to improve patient outcomes.
|
What is dopamine?
The vasopressor proven to be harmful in septic patients.
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What is Reducing duration of shock?
The consistently-proven benefit of giving steroids in septic shock patients?
|
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What are Platelet count, Bilirubin, GCS, Creatinine/urine output?
The 4 elements of the SOFA score other than hypotension and PaO2/FiO2 ratio
|
What is septic cardiomyopathy?
Condition, other than vasodilation, contributing to the shock state in a significant proportions of septic patients.
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What are higher costs and small risks related to administration of blood products?
The two disadvantages of using Albumin 4% for the fluid resuscitation of septic patients.
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What is a decreased need for RRT?
The potential benefit of adding vasopressin to norepinephrine in septic patients.
|
What is Synthesis of catecholamines?
The physiological function of Vitamin C other than anti-oxydant, anti-inflammatory, and anti-thrombotic effects?
|
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What is predicting poor outcome in suspected septic patients?
The utility of the qSOFA score
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What are Pulse pressure variation, IVC collapsibility, and Leg raising test?
Three strategies to monitor fluid responsiveness in ICU patients.
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What is Albios?
Name of the trial looking at the administration of Albumin 20% in severely septic patients.
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What is Nobody?
The septic sub-population who benefits the most of higher BP targets during resuscitation.
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What is up-regulation of pro-coagulants (tissue factor activation) and down-regulation of anti-coagulants (ATIII, APC)
The main types of coagulation abnormalities encountered in sepsis.
|
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What are better specificity and predictive validity?
The Sepsis-3 definition advantages/strengths over the previous definition of sepsis
|
What is the capillary refill?
A monitoring strategy for septic patients at least as effective as serum lactate to guide resuscitation.
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What is a decreased rate of renal failure?
Main potential advantage of using balanced vs. unbalanced crystalloids in critically ill patients.
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What are Low endogenous levels of vasopressin in septic patients and Binding to non-adrenergic receptors
Two theoretical reasons to use vasopressin in addition to norepinephrine in septic patients?
|
What is necrotizing fasciitis?
Indication for IVIG in septic patients
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