oncogene | abbreviation | Tyrosine Kinase | tumor suppressor gene and growth factors |
---|---|---|---|
What is oncogene
this is causing cancer when up-regulated
|
What is the DNA binding domain
this is DBD
|
What is RTK
this have a transmembrane domain
|
What is growth factors
this also contributes to the cancer progression
|
What is activation of proto-oncogene
this is intra mutation, upregulated of proteins, and chromosomal translocation
|
What is the trans-activating domain
this is TAD
|
What is NRTK
This does not have transmembrane domain
|
What is TSG (tumor suppressor gene)
this protects or prevents cancer progression
|
What is Ras
this is a protein that leads to abnormal cellular activity
|
What is the Signal sensing domain
this is SSD
|
What is RTK activation
This caused by ligand bind and a dimer formed
|
What is the function of TSG
this blocks cell division when the condition is not optimal, sense DNA damage, and initiate apoptosis for irreparable cells
|
What is RAS structure
there is G-domain and C-terminal
|
What is a tumor suppressor gene
This is TSG
|
What is Tyrosine kinase
This is used as an on and off function in many cellular functions
|
What is the most well known TSG
There are RB1 and P53
|
What is permanently "on" RAS gene
this prevents GTP hydrolysis,
|
What is a receptor tyrosine kinase
This is RTK
|
What is RTK phosphorylated and activate the system
This happens when RTK receive molecules
|
What is molecular oncology mid tumoro!
this is tiring and hard, but we all know you can do it
|