cancer epigenetics Histone histone & DNA methylation binding domains & miRNAs
100
What is Epigenetics
These studies of genetic effects NOT encoded as DNA sequences
100
What are modifications histone undergoes
there are acetylation, methylation, phosphorylation, ubiquitylation.
100
What is
this is the addition of tyrosine (Y), serine (S), threonine (T), and histidine (H)
100
What is Methyl CpG binding domain (MBD)
this recognized methylated DNA
200
What is epigenetic modulation
There are social interactions, alternative medicine, therapeutic drugs, microbiome, disease exposure, toxic chemicals, drugs abuse.
200
What is writes or erases
this modifies histone structures
200
What is the modification of chromatin architecture
this is exposing its part to gene expression machinery without modifying histone structure
200
What is miRNAs
This is a small non-coding RNAs of 22 nucleotides
300
What are epigenetics and development
There are cell differentiation, epigenetic tags, and reprogramming
300
What is readers
this respond based on histone modifications
300
What is DNA methylation
the process of adding methyl group in DNA nucleotides
300
What is transcriptional silencing
this is causing expressed in a tissue-specific manner and controls biological processes
400
What is epigenetic mechanism
this is chromatin remodeling, DNA methylation, and miRNAs
400
What is acetylation
this causes coil relaxation and deacetylation, causes coil tightening
400
What is the cells preserve and control DNA methylation
this is de novo methylation and maintenance methylation
400
What is miRNAs
this is transcribed from introns of the gene, introns of other genes or other exons
500
What is histone
there are H2A, H2B, H3, and H4
500
What is histone methylation
This is the addition of methyl residues in histone tail
500
What is ways DNA methylation in CpG island can be modified
this is the recruitment of methyl-CpG binding proteins, and directly interfere with polymerase complex
500
What is DICER
this is used to cleave to make a shorter strand






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