cancer epigenetics | Histone | histone & DNA methylation | binding domains & miRNAs |
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What is Epigenetics
These studies of genetic effects NOT encoded as DNA sequences
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What are modifications histone undergoes
there are acetylation, methylation, phosphorylation, ubiquitylation.
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What is
this is the addition of tyrosine (Y), serine (S), threonine (T), and histidine (H)
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What is Methyl CpG binding domain (MBD)
this recognized methylated DNA
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What is epigenetic modulation
There are social interactions, alternative medicine, therapeutic drugs, microbiome, disease exposure, toxic chemicals, drugs abuse.
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What is writes or erases
this modifies histone structures
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What is the modification of chromatin architecture
this is exposing its part to gene expression machinery without modifying histone structure
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What is miRNAs
This is a small non-coding RNAs of 22 nucleotides
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What are epigenetics and development
There are cell differentiation, epigenetic tags, and reprogramming
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What is readers
this respond based on histone modifications
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What is DNA methylation
the process of adding methyl group in DNA nucleotides
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What is transcriptional silencing
this is causing expressed in a tissue-specific manner and controls biological processes
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What is epigenetic mechanism
this is chromatin remodeling, DNA methylation, and miRNAs
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What is acetylation
this causes coil relaxation and deacetylation, causes coil tightening
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What is the cells preserve and control DNA methylation
this is de novo methylation and maintenance methylation
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What is miRNAs
this is transcribed from introns of the gene, introns of other genes or other exons
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What is histone
there are H2A, H2B, H3, and H4
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What is histone methylation
This is the addition of methyl residues in histone tail
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What is ways DNA methylation in CpG island can be modified
this is the recruitment of methyl-CpG binding proteins, and directly interfere with polymerase complex
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What is DICER
this is used to cleave to make a shorter strand
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