this is undifferentiated stem cells that have the ability to differentiate into many different cell types

these are the primary pathway to maintain stemness of CSC

this is notch signaling

this is the conditions that influence the microenvironment of CSC

this is differentiated tumor cells that give rise to diverse tumor populations that proliferate tumorigenesis

this is a diverse family of secreted lipid-modified signaling glycoproteins

this is caused by HES expressed

this is initiated by repression of primary adhesion molecule of epithelial cells

this is disturbed gene regulatory pathways by the proliferation of oncogenes and downregulation of tumor suppressor genes

this is the canonical Wnt Pathway

this is where cells differentiate and express delta

this is detaching of epithelial CSC to become mesenchymal, thus allow CSC to invade other areas

this is can be stem cell-stem cell interaction, adhesive molecules, pH, growth factors, cytokines

this activation causes cell movement

this is proteolytic cleavage and release of the intracellular domain to activate transcription

this is lack of oxygen

this is the conditions that influence the microenvironment of CSC

these are the target genes of Wnt

this is causing the cleaved part of NICD translocates to the nucleus

this is responsible to maintain the hypoxic condition