| Step by Step | Terms | Location | Infantile | Where it's common |
|---|---|---|---|---|
|
Juvenile
Which form of Tay-Sachs is the rarest?
|
A protein
What is Hex-A?
|
Chromosome 15
Where is the defective gene that leads to Tay-Sachs?
|
Quicker progression
What would an earlier of an age symptoms are observed mean for a child?
|
Ashkenazi Jews
Who are the highest risk group?
|
|
Hex-A
What is the name of the protein that isn't made because of the defective gene?
|
Central Nervous System
What part of the body does Tay-Sachs affect?
|
Nerve cells in the brain
Where do the gangliosides accumulate?
|
Before birth (Prenatal)
How early does nerve damage begin in children?
|
Germany
Where are Ashkenazi's Jews from?
|
|
Gangliosides
What accumulates to toxic levels in nerve cells located in the brain?
|
Autosomal
What is the term for chromosomes that are not not sex chromosomes?
|
Central nervous system
What part of the body does Tay-Sachs affect?
|
3 - 6 months of age
When do symptoms usually begin to appear?
|
French Canadians
Which Canadian ethnic group is at higher risk of passing on/receiving the disorder?
|
|
Brain and spinal cord
What does the central nervous system consist of?
|
GM2
(the second monosialic ganglioside discovered)
Which specific ganglioside builds up as a result of the lack of Hex-A?
|
Lysosomes
Where is beta-hexosaminidase A found?
|
2 - 3 years of age
What age do children with the disorder usually pass away at?
|
1 in 27 or
1 in 30
What is the number of carriers found in the Ashkenazi Jewish population?
|
|
Infantile
Which form of Tay-Sachs is most fatal?
|
Neurodegeneration
What is the term associated to brain cell destruction?
|
Around the Mediterranean
(Portugal, Spain, the Middle East and Northern Africa)
Where does the majority of the highest risk group live?
|
'Cherry red' spots in the eye
What is the common identifier of Tay-Sachs in a child?
|
Acadians
Which ethnic group living in Louisiana does Tay-Sachs commonly occur in?
|
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