introduction DNA damage DNA damage and repair random questions in this session.
100
What is DNA damage
This is a physical and chemical modification of DNA
100
What is Inter-strand linkage
this is covalent bonding of nucleotides on a different strand
100
What is DNA damage
this is detrimental to the system, must be eliminated
100
What is Damage Recognition
this is recognition of damaged base by DNA glycosylase.
200
What is the DNA damage causes
There are exogenous and endogenous
200
What is the intrastrand linkage
this is covalent bonding of nucleotides within the same strand
200
What is DNA repair
this is the process of cellular damage identification to sustain the integrity of the genome
200
What is Site nicking or cutting
This AP endonuclease will recognize AP site and cut off the sit, creating nicked DNA strand
300
What is Exogenous DNA damage
There are UV light, x-ray, and carcinogens
300
What is base modifications
this is changing of nucleotides to become unnatural forms
300
What is Cell cycle arrest
this copies all DNA material (damaged or not) and has to be done in order to prevent the passing of DNA damage
300
What is polymerase and ligation
this DNA polymerase recognized nicked site and initiates repair, ended by nick sealing DNA ligase
400
What is Endogenous DNA damage
There is ROS, base deamination, depurination
400
What is Base pair mismatch
this is the replacement of A with G and C with T
400
What is Apoptosis
Can happen due to 2 pathway: p53 dependent or independent
400
What is Homologous recombination
this is a process where two homologous DNA exchange the DNA sequence
500
What are the types of DNA damage
there are base modification, intrastrand linkage, interstrand linkage, and base-pair mismatch
500
What is insertion and deletion
this is an extra nucleotide and deleted nucleotides
500
What is G1/s
This is the primacy decision point known as the restriction point
500
What is Check point activator
this is controlled by two master kinases, ATM and ATR






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